Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.

Gangliosides, sialic acid-containing glycosphingolipids, are abundant in the vertebrate (mammalian) nervous system. Their composition is spatially and developmentally regulated, and gangliosides have been widely believed to lay essential roles in establishment of the nervous system, especially in ne...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Takamiya, K, Yamamoto, A, Furukawa, K, Yamashiro, S, Shin, M, Okada, M, Fukumoto, S, Haraguchi, M, Takeda, N, Fujimura, K, Sakae, M, Kishikawa, M, Shiku, H, Aizawa, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38211/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.10662
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