The Extracellular Chaperone Haptoglobin Prevents Serum Fatty Acid-promoted Amyloid Fibril Formation of β(2)-Microglobulin, Resistance to Lysosomal Degradation, and Cytotoxicity

Fibril formation of β(2)-microglobulin and associated inflammation occur in patients on long term dialysis. We show that the plasma protein haptoglobin prevents the fatty acid-promoted de novo fibril formation of β(2)-microglobulin even at substoichiometric concentration. The fibrils are cytotoxic,...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Sultan, Abdullah, Raman, Bakthisaran, Rao, Ch. Mohan, Tangirala, Ramakrishna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820869/
https://ncbi.nlm.nih.gov/pubmed/24078632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.498337
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares