Decoding a Signature-Based Model of Transcription Cofactor Recruitment Dictated by Cardinal Cis-Regulatory Elements in Proximal Promoter Regions

Genome-wide maps of DNase I hypersensitive sites (DHSs) reveal that most human promoters contain perpetually active cis-regulatory elements between −150 bp and +50 bp (−150/+50 bp) relative to the transcription start site (TSS). Transcription factors (TFs) recruit cofactors (chromatin remodelers, hi...

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Detalhes bibliográficos
Main Authors: Benner, Christopher, Konovalov, Sergiy, Mackintosh, Carlos, Hutt, Kasey R., Stunnenberg, Rieka, Garcia-Bassets, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820735/
https://ncbi.nlm.nih.gov/pubmed/24244184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003906
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