Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death

Numerous mouse models have utilized Cre-loxP technology to modify gene expression. Adverse effects of Cre recombinase activity have been reported, including in the heart. However, the mechanisms associated with cardiac Cre toxicity are largely unknown. Here, we show that expression of Cre in cardiom...

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Detaylı Bibliyografya
Asıl Yazarlar: Bersell, Kevin, Choudhury, Sangita, Mollova, Mariya, Polizzotti, Brian D., Ganapathy, Balakrishnan, Walsh, Stuart, Wadugu, Brian, Arab, Shima, Kühn, Bernhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Limited 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820268/
https://ncbi.nlm.nih.gov/pubmed/23929941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010447
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