Minimal differentiation of classical monocytes as they survey steady state tissues and transport antigen to lymph nodes

It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C(+) monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs). Entry was unaffected in gnotobiotic mice. Monocytes in resting lung and LN had s...

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Hauptverfasser: Jakubzick, Claudia, Gautier, Emmanuel L., Gibbings, Sophie L., Sojka, Dorothy K., Schlitzer, Andreas, Johnson, Theodore E., Ivanov, Stoyan, Duan, Qiaonan, Bala, Shashi, Condon, Tracy, van Rooijen, Nico, Grainger, John R., Belkaid, Yasmine, Ma'ayan, Avi, Riches, David W.H., Yokoyama, Wayne M., Ginhoux, Florent, Henson, Peter M., Randolph, Gwendalyn J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820017/
https://ncbi.nlm.nih.gov/pubmed/24012416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.08.007
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