Combination of the PI3K Inhibitor ZSTK474 with a PSMA-Targeted Immunotoxin Accelerates Apoptosis and Regression of Prostate Cancer

The phosphoinositide 3-kinase (PI3K) pathway is activated in most advanced prostate cancers, yet so far treatments with PI3K inhibitors have been at best tumorostatic in preclinical cancer models and do not show significant antitumor efficacy in clinical trials. Results from tissue culture experimen...

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Autors principals: Baiz, Daniele, Hassan, Sazzad, Choi, Young A, Flores, Anabel, Karpova, Yelena, Yancey, Dana, Pullikuth, Ashok, Sui, Guangchao, Sadelain, Michel, Debinski, Waldemar, Kulik, George
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819633/
https://ncbi.nlm.nih.gov/pubmed/24204196
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