Dietary Iron Enhances Colonic Inflammation and IL-6/IL-11-Stat3 Signaling Promoting Colonic Tumor Development in Mice

Chronic intestinal inflammation and high dietary iron are associated with colorectal cancer development. The role of Stat3 activation in iron-induced colonic inflammation and tumorigenesis was investigated in a mouse model of inflammation-associated colorectal cancer. Mice, fed either an iron-supple...

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Main Authors: Chua, Anita C. G., Klopcic, Borut R. S., Ho, Desiree S., Fu, S. Kristine, Forrest, Cynthia H., Croft, Kevin D., Olynyk, John K., Lawrance, Ian C., Trinder, Debbie
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819375/
https://ncbi.nlm.nih.gov/pubmed/24223168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078850
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