Bone Marrow Deficiency of MCPIP1 Results in Severe Multi-Organ Inflammation but Diminishes Atherogenesis in Hyperlipidemic Mice

OBJECTIVE: MCPIP1 is a newly identified protein that profoundly impacts immunity and inflammation. We aim to test if MCPIP1 deficiency in hematopoietic cells results in systemic inflammation and accelerates atherogenesis in mice. APPROACH AND RESULTS: After lethally irradiated, LDLR(−/−) mice were t...

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Detalhes bibliográficos
Main Authors: Yu, Fang, Du, Fen, Wang, Yuzhen, Huang, Shengping, Miao, Ruidong, Major, Amy S., Murphy, E. Angela, Fu, Mingui, Fan, Daping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819309/
https://ncbi.nlm.nih.gov/pubmed/24223214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080089
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