A Novel Chordoma Xenograft Allows In Vivo Drug Testing and Reveals the Importance of NF-κB Signaling in Chordoma Biology

Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to treat chordoma. The lack of in vivo models of c...

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Detalhes bibliográficos
Main Authors: Trucco, Matteo M., Awad, Ola, Wilky, Breelyn A., Goldstein, Seth D., Huang, Ruili, Walker, Robert L., Shah, Preeti, Katuri, Varalakshmi, Gul, Naheed, Zhu, Yuelin J., McCarthy, Edward F., Paz-Priel, Ido, Meltzer, Paul S., Austin, Christopher P., Xia, Menghang, Loeb, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819300/
https://ncbi.nlm.nih.gov/pubmed/24223206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079950
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