Intra-subject Variability in Human Bone Marrow Stromal Cell (BMSC) Replicative Senescence: Molecular Changes Associated with BMSC Senescence

The outcomes of clinical trials using bone marrow stromal cell (BMSC) are variable; the degree of the expansion of BMSCs during clinical manufacturing may contribute to this variability since cell expansion is limited by senescence. Human BMSCs from aspirates of healthy subjects were subcultured ser...

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Bibliografiske detaljer
Main Authors: Ren, Jiaqiang, Stroncek, David F., Zhao, Yingdong, Jin, Ping, Castiello, Luciano, Civini, Sara, Wang, Huan, Feng, Ji, Tran, Katherine, Kuznetsov, Sergei A., Robey, Pamela G., Sabatino, Marianna
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818332/
https://ncbi.nlm.nih.gov/pubmed/23959330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2013.07.005
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