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Structures of Saccharomyces cerevisiae d-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition
The primary role of yeast Ara1, previously mis-annotated as a d-arabinose dehydrogenase, is to catalyze the reduction of a variety of toxic α,β-dicarbonyl compounds using NADPH as a cofactor at physiological pH levels. Here, crystal structures of Ara1 in apo and NADPH-complexed forms are presented a...
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| Asıl Yazarlar: | , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
International Union of Crystallography
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3818031/ https://ncbi.nlm.nih.gov/pubmed/24192347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309113026857 |
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