Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

Despite extensive study, few therapeutic targets have been identified for glioblastoma (GBM). Here we show that patient derived glioma sphere cultures (GSCs) that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics....

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Autors principals: Bhat, Krishna P.L., Balasubramaniyan, Veerakumar, Vaillant, Brian, Ezhilarasan, Ravesanker, Hummelink, Karlijn, Hollingsworth, Faith, Wani, Khalida, Heathcock, Lindsey, James, Johanna D., Goodman, Lindsey D., Conroy, Siobhan, Long, Lihong, Lelic, Nina, Wang, Suzhen, Gumin, Joy, Raj, Divya, Kodama, Yoshinori, Raghunathan, Aditya, Olar, Adriana, Joshi, Kaushal, Pelloski, Christopher E., Heimberger, Amy, Kim, Se Hoon, Cahill, Daniel P., Rao, Ganesh, Den Dunnen, Wilfred F.A., Boddeke, Hendrikus W.G.M., Phillips, Heidi S., Nakano, Ichiro, Lang, Frederick F., Colman, Howard, Sulman, Erik P., Aldape, Kenneth
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817560/
https://ncbi.nlm.nih.gov/pubmed/23993863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.08.001
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