Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters

Cells react to their environment through gene regulatory networks. Network integrity requires minimization of undesired crosstalk between their biomolecules. Similar constraints also limit the use of regulators when building synthetic circuits for engineering applications. Here, we mapped the promot...

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Hlavní autoři: Rhodius, Virgil A, Segall-Shapiro, Thomas H, Sharon, Brian D, Ghodasara, Amar, Orlova, Ekaterina, Tabakh, Hannah, Burkhardt, David H, Clancy, Kevin, Peterson, Todd C, Gross, Carol A, Voigt, Christopher A
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817407/
https://ncbi.nlm.nih.gov/pubmed/24169405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2013.58
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