Induction of p53-Dependent p21 Limits Proliferative Activity of Rat Hepatocytes in the Presence of Hepatocyte Growth Factor

BACKGROUND: Hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, enhances hepatocyte function without stimulating proliferation, depending on the physiological conditions. p53, a transcription factor, suppresses the cell proliferation by expressing p21(WAF1/CIP1) in various tissues. AIM...

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Detalhes bibliográficos
Main Authors: Inoue, Yukiko, Tomiya, Tomoaki, Nishikawa, Takako, Ohtomo, Natsuko, Tanoue, Yasushi, Ikeda, Hitoshi, Koike, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817248/
https://ncbi.nlm.nih.gov/pubmed/24223793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078346
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