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Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism

OBJECTIVE: Rodents are poor model for human hyperlipidemias because total cholesterol and low density lipoprotein levels are very low on a normal diet. Lipoprotein metabolism is primarily regulated by hepatocytes and we therefore assessed whether chimeric mice extensively repopulated with human cell...

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Detalhes bibliográficos
Main Authors: Ellis, Ewa C. S., Nauglers, Scott, Parini, Paolo, Mörk, Lisa-Mari, Jorns, Carl, Zemack, Helen, Sandblom, Anita Lövgren, Björkhem, Ingemar, Ericzon, Bo-Göran, Wilson, Elizabeth M., Strom, Stephen C., Grompe, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817217/
https://ncbi.nlm.nih.gov/pubmed/24223822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078550
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