Usp16 contributes to somatic stem cell defects in Down syndrome

Down syndrome (DS) results from full or partial trisomy of chromosome 21. However, the consequences of the underlying gene-dosage imbalance on adult tissues remain poorly understood. Here we show that in Ts65Dn mice, trisomic for 132 genes homologous to HSA21, triplication of Usp16 reduces self-rene...

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Hlavní autoři: Adorno, Maddalena, Sikandar, Shaheen, Mitra, Siddhartha S., Kuo, Angera, Di Robilant, Benedetta Nicolis, Haro-Acosta, Veronica, Ouadah, Youcef, Quarta, Marco, Rodriguez, Jacqueline, Qian, Dalong, Reddy, Vadiyala M., Cheshier, Samuel, Garner, Craig C., Clarke, Michael F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816928/
https://ncbi.nlm.nih.gov/pubmed/24025767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12530
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