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Preparation of Fully Synthetic Histone H3 reveals That Acetyl-Lysine 56 Facilitates Protein Binding within Nucleosomes
Post-translational modification (PTM) of histones plays a central role in genome regulation. Engineering histones with defined PTMs on one or multiple residues is crucial for understanding their function within nucleosomes and chromatin. We introduce a sequential native chemical ligation strategy su...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3815667/ https://ncbi.nlm.nih.gov/pubmed/21310161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.01.003 |
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