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Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

AML1 is involved in the (8;21) translocation, associated with acute myelogenous leukemia (AML)-type M2, which results in the production of the AML1-ETO fusion protein: the amino-terminal 177 amino acids of AML1 and the carboxyl-terminal 575 amino acids of ETO. The mechanism by which AML1-ETO accompl...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Rhoades, K L, Hetherington, C J, Rowley, J D, Hiebert, S W, Nucifora, G, Tenen, D G, Zhang, D E
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1996
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38155/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876234/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11895
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