The frequency of α(4)β(7)(high) memory CD4(+) T cells correlates with susceptibility to rectal SIV infection

BACKGROUND: Integrin α(4)β(7) (α(4)β(7)) mediates the homing of CD4+ T cells to gut-associated lymphoid tissues (GALT), which constitute a highly favorable environment for HIV expansion and dissemination. HIV and SIV envelope proteins bind to and signal through α(4)β(7) and during acute infection SI...

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Main Authors: Martinelli, Elena, Veglia, Filippo, Goode, Diana, Guerra-Perez, Natalia, Aravantinou, Meropi, Arthos, James, Piatak, Michael, Lifson, Jeffrey D., Blanchard, James, Gettie, Agegnehu, Robbiani, Melissa
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815485/
https://ncbi.nlm.nih.gov/pubmed/23797688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31829f6e1a
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