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The frequency of α(4)β(7)(high) memory CD4(+) T cells correlates with susceptibility to rectal SIV infection
BACKGROUND: Integrin α(4)β(7) (α(4)β(7)) mediates the homing of CD4+ T cells to gut-associated lymphoid tissues (GALT), which constitute a highly favorable environment for HIV expansion and dissemination. HIV and SIV envelope proteins bind to and signal through α(4)β(7) and during acute infection SI...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3815485/ https://ncbi.nlm.nih.gov/pubmed/23797688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31829f6e1a |
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