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Zygotic Porcn Paternal Allele Deletion in Mice to Model Human Focal Dermal Hypoplasia
In mouse and humans, the X-chromosomal Porcupine homolog (Porcn) gene is required for the acylation and secretion of all 19 Wnt ligands, thus representing a bottleneck in the secretion of Wnt ligands. In humans, mutations in PORCN cause the X-linked dominant syndrome Focal Dermal Hypoplasia (FDH, OM...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3815152/ https://ncbi.nlm.nih.gov/pubmed/24223895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079139 |
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