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Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

HIV-1 replication requires the translocation of viral genome into the nucleus of a target cell. We recently reported the synthesis of an arylene bis(methyl ketone) compound (CNI-H0294) that inhibits nuclear targeting of the HIV-1 genome and thus HIV-1 replication in monocyte cultures. Here we demons...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Popov, S, Dubrovsky, L, Lee, M A, Pennathur, S, Haffar, O, aL-Abed, Y, Tonge, P, Ulrich, P, Rexach, M, Blobel, G, Cerami, A, Bukrinsky, M
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38149/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11859
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