Protein Phosphatase 2A Isoforms Utilizing Aβ Scaffolds Regulate Differentiation through Control of Akt Protein

Protein phosphatase 2A (PP2A) regulates almost all cell signaling pathways. It consists of a scaffolding A subunit to which a catalytic C subunit and one of many regulatory B subunits bind. Of the more than 80 PP2A isoforms, 10% use Aβ as a scaffold. This study demonstrates the isoform-specific func...

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Bibliographic Details
Main Authors: Hwang, Justin H., Jiang, Tao, Kulkarni, Shreya, Faure, Nathalie, Schaffhausen, Brian S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814800/
https://ncbi.nlm.nih.gov/pubmed/24052256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497644
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