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Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

Multiorgan apoptosis occurs during sepsis. Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyt...

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Main Authors: Guo, Ren-Feng, Huber-Lang, Markus, Wang, Xin, Sarma, Vidya, Padgaonkar, Vaishalee A., Craig, Ronald A., Riedemann, Niels C., McClintock, Shannon D., Hlaing, Tommy, Shi, Michael M., Ward, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC381438/
https://ncbi.nlm.nih.gov/pubmed/11086028
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