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Population Growth Inflates the Per-Individual Number of Deleterious Mutations and Reduces Their Mean Effect

This study addresses the question of how purifying selection operates during recent rapid population growth such as has been experienced by human populations. This is not a straightforward problem because the human population is not at equilibrium: population genetics predicts that, on the one hand,...

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Detalhes bibliográficos
Main Authors: Gazave, Elodie, Chang, Diana, Clark, Andrew G., Keinan, Alon
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813877/
https://ncbi.nlm.nih.gov/pubmed/23979573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.153973
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