The Inhibition of Subchondral Bone Lesions Significantly Reversed the Weight-Bearing Deficit and the Overexpression of CGRP in DRG Neurons, GFAP and Iba-1 in the Spinal Dorsal Horn in the Monosodium Iodoacetate Induced Model of Osteoarthritis Pain

BACKGROUND: Chronic pain is the most prominent and disabling symptom of osteoarthritis (OA). Clinical data suggest that subchondral bone lesions contribute to the occurrence of joint pain. The present study investigated the effect of the inhibition of subchondral bone lesions on joint pain. METHODS:...

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Main Authors: Yu, Degang, Liu, Fengxiang, Liu, Ming, Zhao, Xin, Wang, Xiaoqing, Li, Yang, Mao, Yuanqing, Zhu, Zhenan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813732/
https://ncbi.nlm.nih.gov/pubmed/24204985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077824
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