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Fragment-based Binding Efficiency Indices in Bioactive Molecular Design: A Computational Approach to BACE-1 Inhibitors

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibi...

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Main Authors: Razzaghi-Asl, Nima, Ebadi, Ahmad, Edraki, Najmeh, Shahabipour, Sara, Miri, Ramin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Shaheed Beheshti University of Medical Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813291/
https://ncbi.nlm.nih.gov/pubmed/24250649
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