The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-d-Aspartate Receptors

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS. NMDARs govern experience-dependent synaptic plasticity and have been implicated in the pathophysiology of various neuropsychiatric disorders includ...

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Main Authors: Paul, Steven M., Doherty, James J., Robichaud, Albert J., Belfort, Gabriel M., Chow, Brian Y., Hammond, Rebecca S., Crawford, Devon C., Linsenbardt, Andrew J., Shu, Hong-Jin, Izumi, Yukitoshi, Mennerick, Steven J., Zorumski, Charles F.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812502/
https://ncbi.nlm.nih.gov/pubmed/24174662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2619-13.2013
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