Selective trapping of SNO-BSA and GSNO by benzenesulfinic acid sodium salt: mechanistic study of thiosulphonate formation and feasibility as a protein S-nitrosothiol detection strategy

The conversion of S-nitrosothiols to thiosulphonates by reaction with the sodium salt of benzenesulfinic acid (PhSO(2)Na) has been examined in detail with the exemplary substrates S-nitrosoglutathione (GSNO) and S-nitrosylated bovine serum albumin (SNO-BSA). The reaction stoichiometry (2:1, PhSO(2)N...

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Main Authors: Reeves, Benjamin D., Hilmer, Jonathan K., Mellmann, Lisa, Hartzheim, Myra, Poffenberger, Kevin, Johnson, Keith, Joshi, Neelambari, Singel, David J., Grieco, Paul A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811913/
https://ncbi.nlm.nih.gov/pubmed/24187391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.08.011
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