Pharmacokinetic and In Vivo Efficacy Studies of the Mycobactin Biosynthesis Inhibitor Salicyl-AMS in Mice

Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5′-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we cond...

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Detalhes bibliográficos
Main Authors: Lun, Shichun, Guo, Haidan, Adamson, John, Cisar, Justin S., Davis, Tony D., Chavadi, Sivagami Sundaram, Warren, J. David, Quadri, Luis E. N., Tan, Derek S., Bishai, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811451/
https://ncbi.nlm.nih.gov/pubmed/23856770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00918-13
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