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Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

The identification of novel antiretroviral agents is required to provide alternative treatment options for HIV-1-infected patients. The screening of a phenotypic cell-based viral replication assay led to the identification of a novel class of 4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6-one (pyrrolopyrazo...

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Autors principals: Lamorte, Louie, Titolo, Steve, Lemke, Christopher T., Goudreau, Nathalie, Mercier, Jean-François, Wardrop, Elizabeth, Shah, Vaibhav B., von Schwedler, Uta K., Langelier, Charles, Banik, Soma S. R., Aiken, Christopher, Sundquist, Wesley I., Mason, Stephen W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811413/
https://ncbi.nlm.nih.gov/pubmed/23817385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00985-13
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