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High-Level Pacidamycin Resistance in Pseudomonas aeruginosa Is Mediated by an Opp Oligopeptide Permease Encoded by the opp-fabI Operon
Pacidamycins (or uridyl peptide antibiotics) possess selective in vivo activity against Pseudomonas aeruginosa. An important limitation for the therapeutic use of pacidamycins with P. aeruginosa is the high frequency (10(−6) to 10(−7)) at which resistant mutants emerge. To elucidate the mechanism(s)...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3811240/ https://ncbi.nlm.nih.gov/pubmed/23979749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01198-13 |
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