Mutator/Hypermutable Fetal/Juvenile Metakaryotic Stem Cells and Human Colorectal Carcinogenesis

Adult age-specific colorectal cancer incidence rates increase exponentially from maturity, reach a maximum, then decline in extreme old age. Armitage and Doll (1) postulated that the exponential increase resulted from “n” mutations occurring throughout adult life in normal “cells at risk” that initi...

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Detalhes bibliográficos
Main Authors: Kini, Lohith G., Herrero-Jimenez, Pablo, Kamath, Tushar, Sanghvi, Jayodita, Gutierrez, Efren, Hensle, David, Kogel, John, Kusko, Rebecca, Rexer, Karl, Kurzweil, Ray, Refinetti, Paulo, Morgenthaler, Stephan, Koledova, Vera V., Gostjeva, Elena V., Thilly, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811064/
https://ncbi.nlm.nih.gov/pubmed/24195059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00267
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