Rats classified as low or high cocaine locomotor responders: A unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors

Individual differences are a hallmark of drug addiction. Here, we describe a rat model based on differential initial responsiveness to low dose cocaine. Despite similar brain cocaine levels, individual outbred Sprague-Dawley rats exhibit markedly different magnitudes of acute cocaine-induced locomot...

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Detalhes bibliográficos
Main Authors: Yamamoto, Dorothy J., Nelson, Anna M., Mandt, Bruce H., Larson, Gaynor A., Rorabaugh, Jacki M., Ng, Christopher M.C., Barcomb, Kelsey M., Richards, Toni L., Allen, Richard M., Zahniser, Nancy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810384/
https://ncbi.nlm.nih.gov/pubmed/23850581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neubiorev.2013.07.002
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