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Rare Coding Variants in ALPL Are Associated With Low Serum Alkaline Phosphatase and Low Bone Mineral Density
Alkaline phosphatase (ALP) plays an essential role in the regulation of tissue mineralization, and its activity is highly heritable. Guided by genetic associations discovered in a murine model, we hypothesized a role for rare coding variants in determining serum ALP level and bone mineral density (B...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3810303/ https://ncbi.nlm.nih.gov/pubmed/21956185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.527 |
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