Receptor Specificity does not affect Replication or Virulence of the 2009 Pandemic H1N1 Influenza Virus in Mice and Ferrets

Human influenza viruses predominantly bind α2,6 linked sialic acid (SA) while avian viruses bind α2,3 SA-containing complex glycans. Virulence and tissue tropism of influenza viruses have been ascribed to this binding preference. We generated 2009 pandemic H1N1 (pH1N1) viruses with either predominan...

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Detalhes bibliográficos
Main Authors: Lakdawala, Seema S., Shih, Angela R., Jayaraman, Akila, Lamirande, Elaine W., Moore, Ian, Paskel, Myeisha, Sasisekharan, Ram, Subbarao, Kanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810034/
https://ncbi.nlm.nih.gov/pubmed/24074599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.08.011
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