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Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis

Degradation of certain inhibitor of apoptosis proteins (IAPs) appears to be critical in the initiation of apoptosis, but the factors that regulate their degradation in mammalian cells are unknown. Nrdp1/FLRF is a RING finger-containing ubiquitin ligase that catalyzes degradation of the EGF receptor...

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Autors principals: Qiu, Xiao-Bo, Markant, Shirley L, Yuan, Junying, Goldberg, Alfred L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC380992/
https://ncbi.nlm.nih.gov/pubmed/14765125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600075
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