Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart

Many genetic diseases are caused by mutations in cis-acting splicing signals, but few are triggered by defective trans-acting splicing factors. Here we report that tissue-specific ablation of the splicing factor SC35 in the heart causes dilated cardiomyopathy (DCM). Although SC35 was deleted early i...

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Autores principales: Ding, Jian-Hua, Xu, Xiangdong, Yang, Dongmei, Chu, Pao-Hsien, Dalton, Nancy D, Ye, Zhen, Yeakley, Joanne M, Cheng, Heping, Xiao, Rui-Ping, Ross, John, Chen, Ju, Fu, Xiang-Dong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC380988/
https://ncbi.nlm.nih.gov/pubmed/14963485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600054
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