AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

Diabetic microvascular complications have been considered to be mediated by a glucose-driven increase in mitochondrial superoxide anion production. Here, we report that superoxide production was reduced in the kidneys of a steptozotocin-induced mouse model of type 1 diabetes, as assessed by in vivo...

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Detalhes bibliográficos
Main Authors: Dugan, Laura L., You, Young-Hyun, Ali, Sameh S., Diamond-Stanic, Maggie, Miyamoto, Satoshi, DeCleves, Anne-Emilie, Andreyev, Aleksander, Quach, Tammy, Ly, San, Shekhtman, Grigory, Nguyen, William, Chepetan, Andre, Le, Thuy P., Wang, Lin, Xu, Ming, Paik, Kacie P., Fogo, Agnes, Viollet, Benoit, Murphy, Anne, Brosius, Frank, Naviaux, Robert K., Sharma, Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809777/
https://ncbi.nlm.nih.gov/pubmed/24135141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66218
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