Increasing Extracellular Protein Concentration Reduces Intracellular Antiretroviral Drug Concentration and Antiviral Effect

The objective of this study was to develop an in vitro pharmacodynamic (PD) system to test the impact of protein binding on antiretroviral (ARV) drug effect and intracellular ARV distribution. CD4(+) T cells were isolated from peripheral blood mononuclear cells (PBMCs) and exposed to varying and phy...

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Detalhes bibliográficos
Main Authors: Avery, Lindsay B., Zarr, Melissa A., Bakshi, Rahul P., Siliciano, Robert F., Hendrix, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Clinical Trials/Clinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809607/
https://ncbi.nlm.nih.gov/pubmed/23601085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2013.0031
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