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Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy

Astrocytes modulate neuronal activity, synaptic transmission, and behavior by releasing chemical transmitters in a process termed gliotransmission. Whether this process impacts epilepsy in vivo is not known. We show that genetic impairment of transmitter release from astrocytes by the expression of...

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Hlavní autoři: Clasadonte, Jerome, Dong, Jinghui, Hines, Dustin J., Haydon, Philip G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808607/
https://ncbi.nlm.nih.gov/pubmed/24101472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311967110
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