Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

CD47 is a “self marker” that is usually overexpressed on the surface of cancer cells to enable them to escape immunosurveillance. Recognition of CD47 by its receptor, signal regulatory protein α (SIRPα), which is expressed in the macrophages, inhibits phagocytic destruction of cancer cells by the ma...

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Main Authors: Wang, Yuhua, Xu, Zhenghong, Guo, Shutao, Zhang, Lu, Sharma, Arati, Robertson, Gavin P, Huang, Leaf
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808133/
https://ncbi.nlm.nih.gov/pubmed/23774794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.135
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