Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.

Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits overexpressing human LCAT had 15-fold greater plasma LCAT activity that nontransgenic control rabbits. This degree of overexpression was associated with...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Hoeg, J M, Santamarina-Fojo, S, Bérard, A M, Cornhill, J F, Herderick, E E, Feldman, S H, Haudenschild, C C, Vaisman, B L, Hoyt, R F, Demosky, S J, Kauffman, R D, Hazel, C M, Marcovina, S M, Brewer, H B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38077/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876155/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11448
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