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The D3 Bacteriophage α-Polymerase Inhibitor (Iap) Peptide Disrupts O-Antigen Biosynthesis through Mimicry of the Chain Length Regulator Wzz in Pseudomonas aeruginosa

Lysogenic bacteriophage D3 causes seroconversion of Pseudomonas aeruginosa PAO1 from serotype O5 to O16 by inverting the linkage between O-specific antigen (OSA) repeat units from α to β. The OSA units are polymerized by Wzy to modal lengths regulated by Wzz(1) and Wzz(2). A key component of the D3...

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Detalhes bibliográficos
Main Authors: Taylor, Véronique L., Udaskin, Molly L., Islam, Salim T., Lam, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807437/
https://ncbi.nlm.nih.gov/pubmed/23955007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00903-13
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