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Processing of the VP1/2A Junction Is Not Necessary for Production of Foot-and-Mouth Disease Virus Empty Capsids and Infectious Viruses: Characterization of “Self-Tagged” Particles

The foot-and-mouth disease virus (FMDV) capsid protein precursor, P1-2A, is cleaved by 3C(pro) to generate VP0, VP3, VP1, and the peptide 2A. The capsid proteins self-assemble into empty capsid particles or viruses which do not contain 2A. In a cell culture-adapted strain of FMDV (O1 Manisa [Lindhol...

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Bibliographische Detailangaben
Hauptverfasser: Gullberg, Maria, Polacek, Charlotta, Bøtner, Anette, Belsham, Graham J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807367/
https://ncbi.nlm.nih.gov/pubmed/23966400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01863-13
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