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Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease.

DNA vaccines expressing herpes simplex virus type 2 (HSV-2) full-length glycoprotein D (gD), or a truncated form of HSV-2 glycoprotein B (gB) were evaluated for protective efficacy in two experimental models of HSV-2 infection. Intramuscular (i.m.) injection of mice showed that each construction ind...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: McClements, W L, Armstrong, M E, Keys, R D, Liu, M A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38071/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876149/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11414
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