Dopamine-Dependent Compensation Maintains Motor Behavior in Mice with Developmental Ablation of Dopaminergic Neurons

The loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and consequent depletion of striatal dopamine are known to underlie the motor deficits observed in Parkinson's disease (PD). Adaptive changes in dopaminergic terminals and in postsynaptic striatal neurons can compensat...

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Main Authors: Golden, Judith P., DeMaro, Joseph A., Knoten, Amanda, Hoshi, Masato, Pehek, Elizabeth, Johnson, Eugene M., Gereau, Robert W., Jain, Sanjay
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807031/
https://ncbi.nlm.nih.gov/pubmed/24155314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0890-13.2013
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