Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

OBJECTIVE: In this prospective cohort study, we investigated cerebral glucose metabolism reductions on [(18)F]-fluorodeoxyglucose (FDG)-PET in progranulin (GRN) mutation carriers prior to frontotemporal dementia (FTD) onset. METHODS: Nine mutation carriers (age 51.5 ± 13.5 years) and 11 noncarriers...

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Autores principales: Jacova, Claudia, Hsiung, Ging-Yuek R., Tawankanjanachot, Itthipol, Dinelle, Katie, McCormick, Siobhan, Gonzalez, Marjorie, Lee, Hyunsoo, Sengdy, Pheth, Bouchard-Kerr, Phoenix, Baker, Matthew, Rademakers, Rosa, Sossi, Vesna, Stoessl, A. Jon, Feldman, Howard H., Mackenzie, Ian R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806924/
https://ncbi.nlm.nih.gov/pubmed/24005336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182a8237e
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