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Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), b...

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Autors principals: Chianese, Giuseppina, Scala, Fernando, Calcinai, Barbara, Cerrano, Carlo, Dien, Henny A., Kaiser, Marcel, Tasdemir, Deniz, Taglialatela-Scafati, Orazio
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806476/
https://ncbi.nlm.nih.gov/pubmed/23989650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md11093297
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