APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility Factors

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disease, caused by mutations of a single gene named Autoimmune regulator gene (AIRE) which results in a failure of T-cell tolerance. Central tolerance takes place within the thymus and represents th...

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Bibliografski detalji
Glavni autori: De Martino, Lucia, Capalbo, Donatella, Improda, Nicola, D’Elia, Federica, Di Mase, Raffaella, D’Assante, Roberta, D’Acunzo, Ida, Pignata, Claudio, Salerno, Mariacarolina
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2013
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805967/
https://ncbi.nlm.nih.gov/pubmed/24167503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00331
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