5-HTT Deficiency Affects Neuroplasticity and Increases Stress Sensitivity Resulting in Altered Spatial Learning Performance in the Morris Water Maze but Not in the Barnes Maze

The purpose of this study was to evaluate whether spatial hippocampus-dependent learning is affected by the serotonergic system and stress. Therefore, 5-HTT knockout (-/-), heterozygous (+/-) and wildtype (+/+) mice were subjected to the Barnes maze (BM) and the Morris water maze (WM), the latter be...

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Main Authors: Karabeg, Margherita M., Grauthoff, Sandra, Kollert, Sina Y., Weidner, Magdalena, Heiming, Rebecca S., Jansen, Friederike, Popp, Sandy, Kaiser, Sylvia, Lesch, Klaus-Peter, Sachser, Norbert, Schmitt, Angelika G., Lewejohann, Lars
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805519/
https://ncbi.nlm.nih.gov/pubmed/24167611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078238
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